Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation
Identifieur interne : 001678 ( Main/Exploration ); précédent : 001677; suivant : 001679Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation
Auteurs : Takuya Iwasaki [Japon] ; Shigeyuki Itamura [Japon] ; Hidekazu Nishimura [Japon] ; Yuko Sato [Japon] ; Masato Tashiro [Japon] ; Tsutomu Hashikawa [Japon] ; Takeshi Kurata [Japon]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 2004-12-01.
English descriptors
- KwdEn :
Abstract
Abstract: The H5N1 type of influenza A virus isolated from human patients in 1997 has a characteristic hemagglutinin and was considered to be directly transmitted from birds. Although neuropathogenicity of this virus was not demonstrated in human autopsy cases, some experimental studies using mice have disclosed that this virus infects the central nervous system (CNS) after intranasal inoculation. In this study we focused on the topographical localization of virus-infected cells in the murine CNS after intranasal inoculation. We immunohistochemically examined virus-infected cells in mouse tissues using a rabbit antiserum recognizing the nucleoprotein of influenza A virus. The virus-infected cells appeared initially in the respiratory tract. Thereafter, the virus antigen-positive cells appeared in the olfactory system and the cranial nerve nuclei innervating the facial region. This suggests that this virus is principally transmitted from the nasal cavity to CNS through the cranial nerves. Neurons were frequently infected and glial and ependymal cells were also infected. Transneuronal transmission of the virus might play the important role of viral spread within the CNS.
Url:
DOI: 10.1007/s00401-004-0909-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000605
- to stream Istex, to step Curation: 000605
- to stream Istex, to step Checkpoint: 000556
- to stream Main, to step Merge: 001709
- to stream Main, to step Curation: 001678
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation</title>
<author><name sortKey="Iwasaki, Takuya" sort="Iwasaki, Takuya" uniqKey="Iwasaki T" first="Takuya" last="Iwasaki">Takuya Iwasaki</name>
</author>
<author><name sortKey="Itamura, Shigeyuki" sort="Itamura, Shigeyuki" uniqKey="Itamura S" first="Shigeyuki" last="Itamura">Shigeyuki Itamura</name>
</author>
<author><name sortKey="Nishimura, Hidekazu" sort="Nishimura, Hidekazu" uniqKey="Nishimura H" first="Hidekazu" last="Nishimura">Hidekazu Nishimura</name>
</author>
<author><name sortKey="Sato, Yuko" sort="Sato, Yuko" uniqKey="Sato Y" first="Yuko" last="Sato">Yuko Sato</name>
</author>
<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
</author>
<author><name sortKey="Hashikawa, Tsutomu" sort="Hashikawa, Tsutomu" uniqKey="Hashikawa T" first="Tsutomu" last="Hashikawa">Tsutomu Hashikawa</name>
</author>
<author><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3ACAC4FFBA949AEFBD4A2F7A1DECEEDFF62A14BA</idno>
<date when="2004" year="2004">2004</date>
<idno type="doi">10.1007/s00401-004-0909-0</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-PWQS99QZ-J/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000605</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000605</idno>
<idno type="wicri:Area/Istex/Curation">000605</idno>
<idno type="wicri:Area/Istex/Checkpoint">000556</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000556</idno>
<idno type="wicri:doubleKey">0001-6322:2004:Iwasaki T:productive:infection:in</idno>
<idno type="wicri:Area/Main/Merge">001709</idno>
<idno type="wicri:Area/Main/Curation">001678</idno>
<idno type="wicri:Area/Main/Exploration">001678</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation</title>
<author><name sortKey="Iwasaki, Takuya" sort="Iwasaki, Takuya" uniqKey="Iwasaki T" first="Takuya" last="Iwasaki">Takuya Iwasaki</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Clinical Investigation, Institute of Tropical Medicine, Nagasaki University, Sakamoto 1-12-4, 852-8523, Nagasaki</wicri:regionArea>
<wicri:noRegion>Nagasaki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Japon</country>
</affiliation>
</author>
<author><name sortKey="Itamura, Shigeyuki" sort="Itamura, Shigeyuki" uniqKey="Itamura S" first="Shigeyuki" last="Itamura">Shigeyuki Itamura</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Virology III, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nishimura, Hidekazu" sort="Nishimura, Hidekazu" uniqKey="Nishimura H" first="Hidekazu" last="Nishimura">Hidekazu Nishimura</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Virus Reference Center, National Sendai Hospital, Sendai</wicri:regionArea>
<wicri:noRegion>Sendai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sato, Yuko" sort="Sato, Yuko" uniqKey="Sato Y" first="Yuko" last="Sato">Yuko Sato</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Virology III, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hashikawa, Tsutomu" sort="Hashikawa, Tsutomu" uniqKey="Hashikawa T" first="Tsutomu" last="Hashikawa">Tsutomu Hashikawa</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Neural Architecture, Brain Science Institute, Riken, Wako, 351-0198, Saitama</wicri:regionArea>
<wicri:noRegion>Saitama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Acta Neuropathologica</title>
<title level="j" type="abbrev">Acta Neuropathol</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="2004-12-01">2004-12-01</date>
<biblScope unit="volume">108</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="485">485</biblScope>
<biblScope unit="page" to="492">492</biblScope>
</imprint>
<idno type="ISSN">0001-6322</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0001-6322</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain</term>
<term>H5N1</term>
<term>Immunohistochemistry</term>
<term>Influenza virus</term>
<term>Nucleoprotein</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The H5N1 type of influenza A virus isolated from human patients in 1997 has a characteristic hemagglutinin and was considered to be directly transmitted from birds. Although neuropathogenicity of this virus was not demonstrated in human autopsy cases, some experimental studies using mice have disclosed that this virus infects the central nervous system (CNS) after intranasal inoculation. In this study we focused on the topographical localization of virus-infected cells in the murine CNS after intranasal inoculation. We immunohistochemically examined virus-infected cells in mouse tissues using a rabbit antiserum recognizing the nucleoprotein of influenza A virus. The virus-infected cells appeared initially in the respiratory tract. Thereafter, the virus antigen-positive cells appeared in the olfactory system and the cranial nerve nuclei innervating the facial region. This suggests that this virus is principally transmitted from the nasal cavity to CNS through the cranial nerves. Neurons were frequently infected and glial and ependymal cells were also infected. Transneuronal transmission of the virus might play the important role of viral spread within the CNS.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Iwasaki, Takuya" sort="Iwasaki, Takuya" uniqKey="Iwasaki T" first="Takuya" last="Iwasaki">Takuya Iwasaki</name>
</region>
<name sortKey="Hashikawa, Tsutomu" sort="Hashikawa, Tsutomu" uniqKey="Hashikawa T" first="Tsutomu" last="Hashikawa">Tsutomu Hashikawa</name>
<name sortKey="Itamura, Shigeyuki" sort="Itamura, Shigeyuki" uniqKey="Itamura S" first="Shigeyuki" last="Itamura">Shigeyuki Itamura</name>
<name sortKey="Iwasaki, Takuya" sort="Iwasaki, Takuya" uniqKey="Iwasaki T" first="Takuya" last="Iwasaki">Takuya Iwasaki</name>
<name sortKey="Iwasaki, Takuya" sort="Iwasaki, Takuya" uniqKey="Iwasaki T" first="Takuya" last="Iwasaki">Takuya Iwasaki</name>
<name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name>
<name sortKey="Nishimura, Hidekazu" sort="Nishimura, Hidekazu" uniqKey="Nishimura H" first="Hidekazu" last="Nishimura">Hidekazu Nishimura</name>
<name sortKey="Sato, Yuko" sort="Sato, Yuko" uniqKey="Sato Y" first="Yuko" last="Sato">Yuko Sato</name>
<name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001678 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001678 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:3ACAC4FFBA949AEFBD4A2F7A1DECEEDFF62A14BA |texte= Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation }}
This area was generated with Dilib version V0.6.33. |